Novel,cell-permeableinhibitorofproteinkinaseMζ(PKMζ),aconstitutivelyactive,atypicalPKCisozymeinvolvedinLTPmaintenance.SelectivelyblocksPKMζ-inducedsynapticpotentiationinhippocampalslicesinvitro.Reverseslate-phaseLTP(IC50=1-2.5μM)andproducespersistentlossof1-day-oldspatialmemoryfollowingcentraladmiNISTrationinvivo.Controlandbiotinylatedpeptides(Cat.Nos.3215and3290)alsoavailable.
M.Wt | 1982.4 |
Formula | C90H154N30O17 |
Sequence | SIYRRGARRWRKL (Modifications:Ser-1=Myr-Ser) |
Storage | Desiccateat-20°C |
CASNumber | 863987-12-6 |
PubChemID | 16156119 |
InChIKey | CRKARHQCXWSUMV-HOHDCHNJSA-N |
Smiles | [H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto1mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight1982.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.5mL | 2.52mL | 5.04mL |
5mM | 0.1mL | 0.5mL | 1.01mL |
10mM | 0.05mL | 0.25mL | 0.5mL |
50mM | 0.01mL | 0.05mL | 0.1mL |