SelectiveinhibitorofCdc42.TargetsthebindingsiteoftheCdc42guaninenucleotideexchangefactor,intersectin(ITSN).InhibitsCdc42-mediatedcellulareffects,includingmicrospikeformationin3T3fibroblastsandneuronalbranchinginprimaryneonatalcorticalneurons.AlsosuppressescellmotilityandmigrationinPC3cells,withoutcytotoxiceffects.
ZCL278isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 584.89 |
Formula | C21H19BrClN5O4S2 |
Storage | Storeat+4°C |
Purity | ≥95%(HPLC) |
CASNumber | 587841-73-4 |
PubChemID | 1791111 |
InChIKey | XKZDWYDHEBCGCG-UHFFFAOYSA-N |
Smiles | ClC1=C(OCC(NC(NC2=CC=C(S(NC3=NC(C)=CC(C)=N3)(=O)=O)C=C2)=S)=O)C=CC(Br)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 58.49 | 100 |
Thefollowingdataisbasedontheproductmolecularweight584.89.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.71mL | 8.55mL | 17.1mL |
5mM | 0.34mL | 1.71mL | 3.42mL |
10mM | 0.17mL | 0.85mL | 1.71mL |
50mM | 0.03mL | 0.17mL | 0.34mL |