Novel,selectiveinhibitorofinterleukin-5(IL-5)(IC50=0.45-1mM).InhibitsIL-5-prolongedeosinophilsurvivalandIL-5-inducedtyrosinephosphorylationofJAK2withoutinhibitingGM-CSF-mediatedeffects.Inhibitsantigen-inducedeosinophilandlymphocyterecruitmentinratairwaysinvivo,withoutaffectingperipheralbloodorbonemarrowleukocytes.
SoldwiththepermissionofAstellasPharmaInc.
M.Wt | 359.43 |
Formula | C22H21N3O2 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 163769-88-8 |
PubChemID | 1103147 |
InChIKey | HIXSPVQXXDULHS-UHFFFAOYSA-N |
Smiles | COC1=CC2=C(C=C1OC)C1=CC3=NC4=CC=CC=C4N=C3N1C(C)(C)C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 17.97 | 50 | |
ethanol | 8.99 | 25 |
Thefollowingdataisbasedontheproductmolecularweight359.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.78mL | 13.91mL | 27.82mL |
5mM | 0.56mL | 2.78mL | 5.56mL |
10mM | 0.28mL | 1.39mL | 2.78mL |
50mM | 0.06mL | 0.28mL | 0.56mL |