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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/YM 511/3278/50/50 mg
产品编号:3278/50
市  场 价:¥13300.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$665.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/YM 511/3278/50/50 mg
商品介绍
Description:Potentaromatase(CYP19)inhibitor
ChemicalName:4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Orallyactive,potentaromatase(CYP19)inhibitor(IC50valuesare0.4and0.12nMatratovaryandhumanplacentacellsrespectively)thatonlyweaklyinhibitsthesynthesisofothersteroidhormones.Reducesplasmaestrogenlevelsintorangesinducedbyovariectomyandinhibitstestosterone-inducedbreastcancercellgrowthinvitro(IC50=0.13nM).

LicensingInformation

(SoldwiththepermissionofAstellasPharmaInc.)

TechnicalData

M.Wt354.2
FormulaC16H12BrN5
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber148869-05-0
PubChemID177865
InChIKeyGGPPBTSXFROGAE-UHFFFAOYSA-N
SmilesBrC(C=C3)=CC=C3CN(N2C=NN=C2)C1=CC=C(C#N)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO35.42100
ethanol8.8625

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight354.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.82mL14.12mL28.23mL
5mM0.56mL2.82mL5.65mL
10mM0.28mL1.41mL2.82mL
50mM0.06mL0.28mL0.56mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet