Orallyactive,potentaromatase(CYP19)inhibitor(IC50valuesare0.4and0.12nMatratovaryandhumanplacentacellsrespectively)thatonlyweaklyinhibitsthesynthesisofothersteroidhormones.Reducesplasmaestrogenlevelsintorangesinducedbyovariectomyandinhibitstestosterone-inducedbreastcancercellgrowthinvitro(IC50=0.13nM).
(SoldwiththepermissionofAstellasPharmaInc.)
| M.Wt | 354.2 |
| Formula | C16H12BrN5 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 148869-05-0 |
| PubChemID | 177865 |
| InChIKey | GGPPBTSXFROGAE-UHFFFAOYSA-N |
| Smiles | BrC(C=C3)=CC=C3CN(N2C=NN=C2)C1=CC=C(C#N)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.42 | 100 | |
| ethanol | 8.86 | 25 |
Thefollowingdataisbasedontheproductmolecularweight354.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.82mL | 14.12mL | 28.23mL |
| 5mM | 0.56mL | 2.82mL | 5.65mL |
| 10mM | 0.28mL | 1.41mL | 2.82mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |



