请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/YM 244769/4544/10/10 mg
产品编号:4544/10
市  场 价:¥3380.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$169.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/YM 244769/4544/10/10 mg
商品介绍
Description:Na+/Ca2+exchangeinhibitor(reversemode);neuroprotective
ChemicalName:N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamidedihydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofthereversemodeofNa+/Ca2+exchange(NCX).PotentlyinhibitsNa+-dependent45Ca2+uptake(IC50valuesare18,68and96nMforCCL39cellstransfectedwithNCX3,NCX1andNCX2respectively).DisplaysselectivityforNCXoverotherNa+andCa2+transporters.Protectsagainsthypoxia/reoxygenation-inducedcelldamageinneuronalSH-SY5YcellsexpressingNCX1andNCX3.

CompoundLibraries

YM244769isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt516.39
FormulaC26H22FN3O3.2HCl
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber837424-39-2
PubChemID90488952
InChIKeyOCKIUNLKEPKCRE-UHFFFAOYSA-N
SmilesNC1=CC=CC(CNC(C2=CN=C(OC3=CC=C(OCC4=CC=CC(F)=C4)C=C3)C=C2)=O)=C1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO51.64100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight516.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.94mL9.68mL19.37mL
5mM0.39mL1.94mL3.87mL
10mM0.19mL0.97mL1.94mL
50mM0.04mL0.19mL0.39mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet