InhibitorofthereversemodeofNa+/Ca2+exchange(NCX).PotentlyinhibitsNa+-dependent45Ca2+uptake(IC50valuesare18,68and96nMforCCL39cellstransfectedwithNCX3,NCX1andNCX2respectively).DisplaysselectivityforNCXoverotherNa+andCa2+transporters.Protectsagainsthypoxia/reoxygenation-inducedcelldamageinneuronalSH-SY5YcellsexpressingNCX1andNCX3.
YM244769isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 516.39 |
Formula | C26H22FN3O3.2HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 837424-39-2 |
PubChemID | 90488952 |
InChIKey | OCKIUNLKEPKCRE-UHFFFAOYSA-N |
Smiles | NC1=CC=CC(CNC(C2=CN=C(OC3=CC=C(OCC4=CC=CC(F)=C4)C=C3)C=C2)=O)=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 51.64 | 100 |
Thefollowingdataisbasedontheproductmolecularweight516.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.94mL | 9.68mL | 19.37mL |
5mM | 0.39mL | 1.94mL | 3.87mL |
10mM | 0.19mL | 0.97mL | 1.94mL |
50mM | 0.04mL | 0.19mL | 0.39mL |