Nitricoxide-independentactivatorofsolubleguanylylcyclase(sGC).SignificantlyelevatescGMPlevelsandinhibitscollagen-stimulatedaggregationofwashedrabbitplatelets(IC50=14.6μM);inducesrelaxationindenudedphenylephrine-contractedrabbitaorticrings(EC50=1.9μM).AlsodisplaysantiproliferativeactivityinvitroandinvivobyinducingG1cellcyclearrestintwohumanhepatocellularcarcinoma(HCC)celllines,andinHCCxenograftsinathymicSCIDmice.Exhibitslowcytotoxicityinnon-malignantcells.
YC1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 304.34 |
Formula | C19H16N2O2 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 170632-47-0 |
PubChemID | 5712 |
InChIKey | OQQVFCKUDYMWGV-UHFFFAOYSA-N |
Smiles | OCC4=CC=C(O4)C2=NN(CC3=CC=CC=C3)C1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.43 | 100 | |
ethanol | 15.22 | 50 |
Thefollowingdataisbasedontheproductmolecularweight304.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.29mL | 16.43mL | 32.86mL |
5mM | 0.66mL | 3.29mL | 6.57mL |
10mM | 0.33mL | 1.64mL | 3.29mL |
50mM | 0.07mL | 0.33mL | 0.66mL |