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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/YC 1/4307/10/10 mg
产品编号:4307/10
市  场 价:¥3780.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$189.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/YC 1/4307/10/10 mg
商品介绍
Description:Solubleguanylylcyclase(sGC)activator;inducesG1cellcyclearrest
ChemicalName:3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Nitricoxide-independentactivatorofsolubleguanylylcyclase(sGC).SignificantlyelevatescGMPlevelsandinhibitscollagen-stimulatedaggregationofwashedrabbitplatelets(IC50=14.6μM);inducesrelaxationindenudedphenylephrine-contractedrabbitaorticrings(EC50=1.9μM).AlsodisplaysantiproliferativeactivityinvitroandinvivobyinducingG1cellcyclearrestintwohumanhepatocellularcarcinoma(HCC)celllines,andinHCCxenograftsinathymicSCIDmice.Exhibitslowcytotoxicityinnon-malignantcells.

CompoundLibraries

YC1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt304.34
FormulaC19H16N2O2
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber170632-47-0
PubChemID5712
InChIKeyOQQVFCKUDYMWGV-UHFFFAOYSA-N
SmilesOCC4=CC=C(O4)C2=NN(CC3=CC=CC=C3)C1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO30.43100
ethanol15.2250

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight304.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.29mL16.43mL32.86mL
5mM0.66mL3.29mL6.57mL
10mM0.33mL1.64mL3.29mL
50mM0.07mL0.33mL0.66mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet