ProdrugoftheKir6(KATP)channelopenerY-26763(Cat.No.2076).Inactiveinvitro;failstomodifytensionincontractedaorticringsatconcentrationsupto1mM.Produceslong-lastingantihypertensiveeffectsinvivo,withminimaltachycardiafollowingoraladmiNISTrationinhypertensiveanimals.
| M.Wt | 366.41 |
| Formula | C21H22N2O4 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 127408-30-4 |
| PubChemID | 6918184 |
| InChIKey | RHFUXPCCELGMFC-UXHICEINSA-N |
| Smiles | CC(=O)N(OCC1=CC=CC=C1)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.16 | 25 | |
| ethanol | 1.83 | 5mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight366.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.73mL | 13.65mL | 27.29mL |
| 5mM | 0.55mL | 2.73mL | 5.46mL |
| 10mM | 0.27mL | 1.36mL | 2.73mL |
| 50mM | 0.05mL | 0.27mL | 0.55mL |



