ProdrugoftheKir6(KATP)channelopenerY-26763(Cat.No.2076).Inactiveinvitro;failstomodifytensionincontractedaorticringsatconcentrationsupto1mM.Produceslong-lastingantihypertensiveeffectsinvivo,withminimaltachycardiafollowingoraladmiNISTrationinhypertensiveanimals.
M.Wt | 366.41 |
Formula | C21H22N2O4 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 127408-30-4 |
PubChemID | 6918184 |
InChIKey | RHFUXPCCELGMFC-UXHICEINSA-N |
Smiles | CC(=O)N(OCC1=CC=CC=C1)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 9.16 | 25 | |
ethanol | 1.83 | 5mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight366.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.73mL | 13.65mL | 27.29mL |
5mM | 0.55mL | 2.73mL | 5.46mL |
10mM | 0.27mL | 1.36mL | 2.73mL |
50mM | 0.05mL | 0.27mL | 0.55mL |