Selectiveestrogenreceptormodulator(SERM)thatdisplaysselectivityforERαoverERβ(Kivaluesare0.09and11.31nMrespectively)andnocross-reactivitywithmineralocorticoid,glucocorticoid,androgenandprogesteronereceptors.ActsasanagoNISTintheboneandantagonistinreproductivetissue.Suppressesestrogen-stimulatedproliferationofER-positivehumanbreastcancerMCF-7andT47Dcells.
Y134isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 472.6 |
Formula | C28H28N2O3S |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 849662-80-2 |
PubChemID | 11784736 |
InChIKey | LQEOPHGPHCWOAC-UHFFFAOYSA-N |
Smiles | CC(C)N1CCN(CC1)C1=CC=C(C=C1)C(=O)C1=C(SC2=CC(O)=CC=C12)C1=CC=C(O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 47.26 | 100 | |
ethanol | 47.26 | 100 |
Thefollowingdataisbasedontheproductmolecularweight472.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.12mL | 10.58mL | 21.16mL |
5mM | 0.42mL | 2.12mL | 4.23mL |
10mM | 0.21mL | 1.06mL | 2.12mL |
50mM | 0.04mL | 0.21mL | 0.42mL |