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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/WAY 252623/5951/10/10 mg
产品编号:5951/10
市  场 价:¥2980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$149.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/WAY 252623/5951/10/10 mg
商品介绍
Description:PotentLXRagoNIST
ChemicalName:2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentLXRagonist(IC50valuesare24and179nMforLXRβandLXRα,respectively).ReducestotalserumcholesterolandLDLcholesterol,andinhibitslesiongrowthinmodelsofatherosclerosis.IncreasesABCA1andABCG1mRNAlevelsinratperipheralbloodcells.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt422.78
FormulaC21H12ClF5N2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber875787-07-8
PubChemID16734800
InChIKeyKYWWJENKIMRJBI-UHFFFAOYSA-N
SmilesClC1=CC(F)=CC=C1CN2N=C3C(C(F)(F)F)=CC=CC3=C2C4=CC=C(F)C=C4

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO42.28100
ethanol42.28100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight422.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.37mL11.83mL23.65mL
5mM0.47mL2.37mL4.73mL
10mM0.24mL1.18mL2.37mL
50mM0.05mL0.24mL0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet