ReportedinhibitorofIP3-dependentCa2+release.Inhibitsbradykinin-inducedCa2+releaseinPC12cellsandattenuatesPHP-inducedIL-2productioninJurkatTcells.Exhibitsnoeffectonryanodinereceptor-mediatedCa2+releaseinPC12cells.DoesnotinteractwiththeIP3bindingsite.RecentlyshowntobeanineffectiveantagoNISTofIP3-evokedCa2+releaseinIP3receptorexpressingDT40cells.Cellpermeable.
M.Wt | 446.71 |
Formula | C28H50N2O2 |
Storage | Desiccateat-20°C |
CASNumber | 88903-69-9 |
PubChemID | 9846431 |
InChIKey | PQYOPBRFUUEHRC-HCKQMYSWSA-N |
Smiles | [H][C@]12[C@@H](CCCCCC[C@@H]3CCN(CCC[C@H]4CCCCCC5)[C@@]4([H])O3)CCCN1CC[C@@H]5O2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 0.89 | 2 | |
ethanol | 0.89 | 2 |
Thefollowingdataisbasedontheproductmolecularweight446.71.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.24mL | 11.19mL | 22.39mL |
5mM | 0.45mL | 2.24mL | 4.48mL |
10mM | 0.22mL | 1.12mL | 2.24mL |
50mM | 0.04mL | 0.22mL | 0.45mL |