FunctionallyselectivemuscarinicM1receptoragonist(EC50valuesare0.3,5,42,52and92.5nMatM1,M3,M5,M4andM2receptorsrespectively).Displaysacomplexpharmacologicalprofile:reversIBLeandwash-resistantbinding,resultinginfullagonistactivityatM1;delayedwash-resistantpartialagonistactivityatM2;anddelayedwash-resistantfullagonistactivityatM4.Exhibitsantipsychoticactivity,andimprovescognitivedeficitsandbehavioraldisturbancesinAlzheimer'sdiseaseandschizophrenia.
XanomelineoxalateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 371.46 |
Formula | C14H23N3OS.C2H2O4 |
Storage | Desiccateat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 141064-23-5 |
PubChemID | 18920248 |
InChIKey | ZJOUESNWCLASJP-UHFFFAOYSA-N |
Smiles | CCCCCCOC1=NSN=C1C2=CCCN(C)C2.OC(C(O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.15 | 100 | |
ethanol | 9.29 | 25 | |
water | 3.71 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight371.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.69mL | 13.46mL | 26.92mL |
5mM | 0.54mL | 2.69mL | 5.38mL |
10mM | 0.27mL | 1.35mL | 2.69mL |
50mM | 0.05mL | 0.27mL | 0.54mL |