PotentVEGFRinhibitor(IC50=0.035nM);alsoinhibitsc-Met,KIT,RET,FLT4,AXL,FLT3,FLT1andTie2(IC50valuesare1.3,4.6,5.2,6,7,11.3,12and14.3nM,respectively).Inducesintratumoralhypoxiaandapoptosis.Reducestumorinvasionandmetastasisinvivo.Antiangiogenic.
XL184isalsoofferedaspartoftheTocriscreenKinaseInhibitorToolboxIIandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 501.51 |
Formula | C28H24FN3O5 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 849217-68-1 |
PubChemID | 25102847 |
InChIKey | ONIQOQHATWINJY-UHFFFAOYSA-N |
Smiles | COC1=CC2=C(C=C1OC)N=CC=C2OC3=CC=C(NC(C4(CC4)C(NC5=CC=C(F)C=C5)=O)=O)C=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 50.15 | 100 |
Thefollowingdataisbasedontheproductmolecularweight501.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.99mL | 9.97mL | 19.94mL |
5mM | 0.4mL | 1.99mL | 3.99mL |
10mM | 0.2mL | 1mL | 1.99mL |
50mM | 0.04mL | 0.2mL | 0.4mL |