SelectiveERRαantagonist/inverseagonist(IC50=~400nM).DisplaysnoantagonistactivityatERRγorERαatconcentrationsbelow10μM.InterfereswithPPARγcoactivator-1α(PGC-1α)/ERRα-dependentsignaling:inhibitsPGC-1αinductionofERRαandMAO-BgeneexpressionanddownregulatestheconstitutivetranscriptionalactivityofERRαinnumerouscelllines.
M.Wt | 596.42 |
Formula | C23H13F9N4O3S |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 725247-18-7 |
PubChemID | 6918788 |
InChIKey | HQFNFOOGGLSBBT-AWNIVKPZSA-N |
Smiles | O=C(NC3=NN=C(C(F)(F)F)S3)/C(C#N)=C/C(C=C2OC)=CC=C2OCC1=C(C(F)(F)F)C=C(C(F)(F)F)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 5.96 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight596.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.68mL | 8.38mL | 16.77mL |
5mM | 0.34mL | 1.68mL | 3.35mL |
10mM | 0.17mL | 0.84mL | 1.68mL |
50mM | 0.03mL | 0.17mL | 0.34mL |