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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/XCT 790/3928/10/10 mg
产品编号:3928/10
市  场 价:¥3380.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$169.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/XCT 790/3928/10/10 mg
商品介绍
Description:SelectiveERRαantagoNIST/inverseagonist
ChemicalName:3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiADIazol-2-yl)acrylamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveERRαantagonist/inverseagonist(IC50=~400nM).DisplaysnoantagonistactivityatERRγorERαatconcentrationsbelow10μM.InterfereswithPPARγcoactivator-1α(PGC-1α)/ERRα-dependentsignaling:inhibitsPGC-1αinductionofERRαandMAO-BgeneexpressionanddownregulatestheconstitutivetranscriptionalactivityofERRαinnumerouscelllines.

TechnicalData

M.Wt596.42
FormulaC23H13F9N4O3S
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber725247-18-7
PubChemID6918788
InChIKeyHQFNFOOGGLSBBT-AWNIVKPZSA-N
SmilesO=C(NC3=NN=C(C(F)(F)F)S3)/C(C#N)=C/C(C=C2OC)=CC=C2OCC1=C(C(F)(F)F)C=C(C(F)(F)F)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO5.9610mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight596.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.68mL8.38mL16.77mL
5mM0.34mL1.68mL3.35mL
10mM0.17mL0.84mL1.68mL
50mM0.03mL0.17mL0.34mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet