Potenttankyrase(TNKS)inhibitor(IC50valuesare4and11nMforTNKS2andTNKS1respectively).AntagonizesWntsignalingviastimulationofβ-catenindegradationandstABIlizationofaxin.Inhibitsproliferationoftheβ-catenin-dependentcoloncarcinomacelllineDLD-1.PromotescardiomyogenicdevelopmentinmesodermProgenitorcells.
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofXAV939isreviewedonthechemicalprobeswebsite.
XAV939isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 312.31 |
Formula | C14H11F3N2OS |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 284028-89-3 |
PubChemID | 2726824 |
InChIKey | KLGQSVMIPOVQAX-UHFFFAOYSA-N |
Smiles | OC1=C(CSCC2)C2=NC(C3=CC=C(C(F)(F)F)C=C3)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 6.25 | 20 |
Thefollowingdataisbasedontheproductmolecularweight312.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.2mL | 16.01mL | 32.02mL |
5mM | 0.64mL | 3.2mL | 6.4mL |
10mM | 0.32mL | 1.6mL | 3.2mL |
50mM | 0.06mL | 0.32mL | 0.64mL |