Orallyactiveα-glucosidaseinhibitor(IC50valuesare3.9and6.4nMatsucraseandmaltaserespectively).Increasesglucagon-likepeptide1(GLP-1)secretionanddecreasesfoodconsumptioninob/obmice,andreducesplasmaconcentrationsofglucose,triglyceridesandinsulininWistarfattyrats.Exhibitsantidiabeticandantiobesityactivityinvivo.
VogliboseisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 267.28 |
Formula | C10H21NO7 |
Storage | Storeat-20°C |
CASNumber | 83480-29-9 |
PubChemID | 444020 |
InChIKey | FZNCGRZWXLXZSZ-CIQUZCHMSA-N |
Smiles | O[C@@H]1[C@](CO)(O)C[C@H](NC(CO)CO)[C@H](O)[C@H]1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 20.05 | 75 | |
water | 26.73 | 100 |
Thefollowingdataisbasedontheproductmolecularweight267.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.74mL | 18.71mL | 37.41mL |
5mM | 0.75mL | 3.74mL | 7.48mL |
10mM | 0.37mL | 1.87mL | 3.74mL |
50mM | 0.07mL | 0.37mL | 0.75mL |