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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Vinorelbine ditartrate/3401/10/10 mg
产品编号:3401/10
市  场 价:¥2780.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$139.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Vinorelbine ditartrate/3401/10/10 mg
商品介绍
Description:SelectivemitoticmicrotubuleantagoNIST
AlternativeNames:Navelbine
ChemicalName:(2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylicacidmethylester
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectivemitoticmicrotubuleantagonistthatexhibits>20foldselectivityoveraxonalmicrotubules.Inhibitsproliferationofmultiplehumantumorcelllines(IC50=1.25nMinHeLacells)andblocksmetaphase/anaphasetransitionbysuppressionofmicrotubuledynamics(IC50=3.8nM).Reducesspindlelengthby29%andinhibitsmicrotubulepolymerizationatmicromolarconcentrations.

TechnicalData

M.Wt1079.1
FormulaC45H54N4O8.2C4H6O6
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber125317-39-7
PubChemID5311497
InChIKeyGBABOYUKABKIAF-IELIFDKJSA-N
Smiles[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@](C7=C(C9)C(C=CC=C8)=C8N7)([C@](OC)=O)C[C@]6([H])C=C(CC)CN9C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O.O=C(O)C(O)C(O)C(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO107.91100
water107.91100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1079.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.93mL4.63mL9.27mL
5mM0.19mL0.93mL1.85mL
10mM0.09mL0.46mL0.93mL
50mM0.02mL0.09mL0.19mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet