Selectivemitoticmicrotubuleantagonistthatexhibits>20foldselectivityoveraxonalmicrotubules.Inhibitsproliferationofmultiplehumantumorcelllines(IC50=1.25nMinHeLacells)andblocksmetaphase/anaphasetransitionbysuppressionofmicrotubuledynamics(IC50=3.8nM).Reducesspindlelengthby29%andinhibitsmicrotubulepolymerizationatmicromolarconcentrations.
M.Wt | 1079.1 |
Formula | C45H54N4O8.2C4H6O6 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 125317-39-7 |
PubChemID | 5311497 |
InChIKey | GBABOYUKABKIAF-IELIFDKJSA-N |
Smiles | [H][C@@]23N(C)C1=CC(OC)=[C@]([C@@](C7=C(C9)C(C=CC=C8)=C8N7)([C@](OC)=O)C[C@]6([H])C=C(CC)CN9C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O.O=C(O)C(O)C(O)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 107.91 | 100 | |
water | 107.91 | 100 |
Thefollowingdataisbasedontheproductmolecularweight1079.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.93mL | 4.63mL | 9.27mL |
5mM | 0.19mL | 0.93mL | 1.85mL |
10mM | 0.09mL | 0.46mL | 0.93mL |
50mM | 0.02mL | 0.09mL | 0.19mL |