YAPinhibitor;disruptsYAP-TEADinteractions.EnhancestrypsincleavageofYAP(EC50=100nM).Inhibitsgrowthandproliferationofretinoblastomacells.Alsosuppressescancerstemcellpropertiesinvitro.SuppressesYAP-inducedliverovergrowthinmice.
M.Wt | 718.79 |
Formula | C41H42N4O8 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 129497-78-5 |
PubChemID | 5362420 |
InChIKey | YTZALCGQUPRCGW-ZSFNYQMMSA-N |
Smiles | CC(C(/C=C4N/C([C@@]5(C)C4=CC=C(C(OC)=O)[C@H]5[C@](OC)=O)=CC6=NC(C(CCC(OC)=O)=C6C)=C3)=N2)=C(C=C)/C2=C/C1=C(C)C(CCC(O)=O)=C/3N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 14.38 | 20 |
Thefollowingdataisbasedontheproductmolecularweight718.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.39mL | 6.96mL | 13.91mL |
5mM | 0.28mL | 1.39mL | 2.78mL |
10mM | 0.14mL | 0.7mL | 1.39mL |
50mM | 0.03mL | 0.14mL | 0.28mL |