SelectiveK+ionophore(K0.5valuesare48,73,75,93and246mMforK+,Rb+,Cs+,Na+andLi+respectively)thattransportsK+acrossbiologicalandartificiallipidmembranes.InhibitsCa2+-ATPaseactivityandinducesapoptosisthroughmitochondrialmembranedepolarization,caspase-3activationandphosphatidylserinetranslocationinvitro.
M.Wt | 1111.32 |
Formula | C54H90N6O18 |
Storage | Desiccateat-20°C |
CASNumber | 2001-95-8 |
PubChemID | 3000706 |
InChIKey | FCFNRCROJUBPLU-DNDCDFAISA-N |
Smiles | O=C([C@H](C)OC([C@@H]([C@@H](C)C)NC([C@H](OC([C@@H](NC([C@@H](O1)C)=O)[C@@H](C)C)=O)[C@@H](C)C)=O)=O)N[C@@H]([C@@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@@H](C(O[C@@H](C)C(N[C@@H]([C@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@H]([C@H](C)C)C1=O)=O)=O)=O)=O)[C@H](C)C)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 27.78 | 25 | |
ethanol | 27.78 | 25 |
Thefollowingdataisbasedontheproductmolecularweight1111.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.9mL | 4.5mL | 9mL |
5mM | 0.18mL | 0.9mL | 1.8mL |
10mM | 0.09mL | 0.45mL | 0.9mL |
50mM | 0.02mL | 0.09mL | 0.18mL |