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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/VU 0463271/4719/50/50 mg
产品编号:4719/50
市  场 价:¥13700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$685.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/VU 0463271/4719/50/50 mg
商品介绍
Description:PotentandselectiveKCC2inhibitor
ChemicalName:N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveinhibitoroftheneuronalK-Clcotransporter,KCC2(IC50=61nM);displays>100-foldselectivityversustheNa-K-2Clcotransporter1(NKCC1)andnoactivityagainstapanelof68GPCRs,ionchannelsandtransporters.

TechnicalData

M.Wt382.5
FormulaC19H18N4OS2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1391737-01-1
PubChemID70690453
InChIKeyDPONSKCACOZTGN-UHFFFAOYSA-N
SmilesO=C(N(C4CC4)C3=NC(C)=CS3)CSC(C=C2)=NN=C2C1=CC=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO19.1250
ethanol3.8310mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight382.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.61mL13.07mL26.14mL
5mM0.52mL2.61mL5.23mL
10mM0.26mL1.31mL2.61mL
50mM0.05mL0.26mL0.52mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet