InhibitoroftheneuronalK-Clcotransporter,KCC2(IC50=560nMforK+uptakeassayinKCC2-overexpressingcells).ExhibitsselectivityovertheNa-K-2Clcotransporter,NKCCl.AlsoinhibitshERGandL-typeCa2+channels.
M.Wt | 342.43 |
Formula | C16H14N4OS2 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 893990-34-6 |
PubChemID | 7211972 |
InChIKey | WJRWSLORVIHRNX-UHFFFAOYSA-N |
Smiles | O=C(NC3=NC(C)=CS3)CSC(C=C2)=NN=C2C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 34.24 | 100 | |
ethanol | 8.56 | 25 |
Thefollowingdataisbasedontheproductmolecularweight342.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.92mL | 14.6mL | 29.2mL |
5mM | 0.58mL | 2.92mL | 5.84mL |
10mM | 0.29mL | 1.46mL | 2.92mL |
50mM | 0.06mL | 0.29mL | 0.58mL |