Noveladenosine-derivedinhibitorofHeatShockProtein70(Hsp70)(IC50=0.5μM).Inhibitscellproliferationofmultiplehumantumorcelllinesinvitro.AlsobindsHsc70andGrp78;displaysselectivityagainstHsp90β(IC50>200μMforHsp90β).
VER155008isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 556.4 |
Formula | C25H23Cl2N7O4 |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 1134156-31-2 |
PubChemID | 25195348 |
InChIKey | ZXGGCBQORXDVTE-UMCMBGNQSA-N |
Smiles | NC1=NC=NC2=C1N=C(NCC5=CC=C(Cl)C(Cl)=C5)N2[C@@H]3O[C@H](COCC4=CC=C(C#N)C=C4)[C@@H](O)[C@H]3O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 55.64 | 100 |
Thefollowingdataisbasedontheproductmolecularweight556.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.8mL | 8.99mL | 17.97mL |
5mM | 0.36mL | 1.8mL | 3.59mL |
10mM | 0.18mL | 0.9mL | 1.8mL |
50mM | 0.04mL | 0.18mL | 0.36mL |