Potentandselectivefattyacidamidehydrolase(FAAH)inhibitor(IC50valuesare3and5nMinhumanliverandratbrain,respectively).Exhibitsnosignificantinhibitoryactivityagainstavarietyofreceptors,ionchannelsandenzymes,includinghumancannABInoidreceptorsandratmonoacylglycerollipase.Displaysantiallodynicandantihyperalgesicactivityinaninflammatorypainmodel.
URB597isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 338.4 |
Formula | C20H22N2O3 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 546141-08-6 |
PubChemID | 1383884 |
InChIKey | ROFVXGGUISEHAM-UHFFFAOYSA-N |
Smiles | NC(C1=CC(C2=CC=CC(OC(NC3CCCCC3)=O)=C2)=CC=C1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 16.92 | 50 |
Thefollowingdataisbasedontheproductmolecularweight338.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.96mL | 14.78mL | 29.55mL |
5mM | 0.59mL | 2.96mL | 5.91mL |
10mM | 0.3mL | 1.48mL | 2.96mL |
50mM | 0.06mL | 0.3mL | 0.59mL |