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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/UC 112/5251/10/10 mg
产品编号:5251/10
市  场 价:¥3780.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$189.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/UC 112/5251/10/10 mg
商品介绍
Description:IAPandXIAPinhibitor;antitumor
ChemicalName:5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

IAPinhibitor(IC50valuesfrom0.7-3.4μM);inhibitscellgrowthinmultiplecancercelllinesandinamelanomaxenograftmodelinvivo.AlsosuppressesX-linkedinhibitorofapoptosisprotein(XIAP)andsurvivinlevels.InhibitsthegrowthofP-glycoproteinsandactivatescaspase-3/7andcaspase-9.

CompoundLibraries

UC112isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt348.44
FormulaC22H24N2O2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber383392-66-3
PubChemID3426979
InChIKeyLTGLGIQQZXSLLF-UHFFFAOYSA-N
SmilesOC1=C3C(C=CC=N3)=C(COCC4=CC=CC=C4)C=C1CN2CCCC2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO34.84100
ethanol6.9720mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight348.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.87mL14.35mL28.7mL
5mM0.57mL2.87mL5.74mL
10mM0.29mL1.43mL2.87mL
50mM0.06mL0.29mL0.57mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet