IAPinhibitor(IC50valuesfrom0.7-3.4μM);inhibitscellgrowthinmultiplecancercelllinesandinamelanomaxenograftmodelinvivo.AlsosuppressesX-linkedinhibitorofapoptosisprotein(XIAP)andsurvivinlevels.InhibitsthegrowthofP-glycoproteinsandactivatescaspase-3/7andcaspase-9.
UC112isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 348.44 |
Formula | C22H24N2O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 383392-66-3 |
PubChemID | 3426979 |
InChIKey | LTGLGIQQZXSLLF-UHFFFAOYSA-N |
Smiles | OC1=C3C(C=CC=N3)=C(COCC4=CC=CC=C4)C=C1CN2CCCC2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 34.84 | 100 | |
ethanol | 6.97 | 20mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight348.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.87mL | 14.35mL | 28.7mL |
5mM | 0.57mL | 2.87mL | 5.74mL |
10mM | 0.29mL | 1.43mL | 2.87mL |
50mM | 0.06mL | 0.29mL | 0.57mL |