AllostericantagonistofP2Y1(EC50=0.06-0.3μM).Non-nucleotideligand.Bindsreceptoroutsideofthehelicalbundle.Blocksinhibitionofspontaneouscontractionofratandmousecoloninducedbyelectricalfieldstimulation,nicotineandP2Yagonists.Antithrombotic;reducesplateletaggregation.
M.Wt | 445.43 |
Formula | C23H22F3N3O3 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 870544-59-5 |
PubChemID | 11510579 |
InChIKey | AHFLGPTXSIRAQK-UHFFFAOYSA-N |
Smiles | CC(C)(C1=C(C=CC=C1)OC2=C(C=CC=N2)NC(NC3=CC=C(C=C3)OC(F)(F)F)=O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 44.54 | 100 | |
ethanol | 44.54 | 100 |
Thefollowingdataisbasedontheproductmolecularweight445.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.25mL | 11.23mL | 22.45mL |
5mM | 0.45mL | 2.25mL | 4.49mL |
10mM | 0.22mL | 1.12mL | 2.25mL |
50mM | 0.04mL | 0.22mL | 0.45mL |