Fluoroquinoloneantibiotic.InhibitsbacterialDNAtopoisomeraseIVandDNAgyraseandformsastablequinolone-DNAcomplexwiththeseenzymeswhichreversIBLyinhibitsDNAsynthesis.Displayspotentactivityagainstgram-positiveandgram-negativebacteria.IncreasestheproductionofmitochondrialNOinimmortalizedhepatocytes;alsoincreasesmitochondrialCa2+.InhibitsPanx-1(IC50~4μM).
SoldforresearchpurposesunderagreementfromPfizerInc.
TrovafloxacinmesylateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 512.46 |
Formula | C20H15F3N4O3.CH3SO3H |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 147059-75-4 |
PubChemID | 62960 |
InChIKey | DYNZICQDCVYXFW-GIPYJWDTSA-N |
Smiles | O=C2C1=CC(F)=C(N4C[C@@]([C@H]5N)([H])[C@@]5([H])C4)N=C1N(C3=C(F)C=C(F)C=C3)C=C2C(O)=O.CS(=O)(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 51.25 | 100 | |
water | 25.62 | 50 |
Thefollowingdataisbasedontheproductmolecularweight512.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.95mL | 9.76mL | 19.51mL |
5mM | 0.39mL | 1.95mL | 3.9mL |
10mM | 0.2mL | 0.98mL | 1.95mL |
50mM | 0.04mL | 0.2mL | 0.39mL |