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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Troglitazone/3114/50/50 mg
产品编号:3114/50
市  场 价:¥10380.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$519.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Troglitazone/3114/50/50 mg
商品介绍
Description:SelectivePPARγagoNIST;antidiabeticagent
AlternativeNames:Rezulin
ChemicalName:5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectivePPARγreceptoragonist(EC50valuesare780and555nMatmurineandhumanPPARγreceptorsrespectively).DisplaysnoactivityatPPARαorPPARδreceptors.Antidiabeticagent;exertspotentglucose-loweringeffectsininsulin-resistantdiabeticmice.Displaysanti-invasiveeffectonhumanbreastcancercells;reducesmigration,adhesionandspreADIngonfibronectin-coatedplates.Alsoinhibitscellgrowthofhematopoieticcelllines.Inhibitslamellipodiaformationandactinpolymerization.

CompoundLibraries

TroglitazoneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt441.54
FormulaC24H27NO5S
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber97322-87-7
PubChemID5591
InChIKeyGXPHKUHSUJUWKP-UHFFFAOYSA-N
SmilesCC1=C2C(CCC(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)(C)O2)=C(C)C(O)=C1C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO44.15100
ethanol4.4210

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight441.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.26mL11.32mL22.65mL
5mM0.45mL2.26mL4.53mL
10mM0.23mL1.13mL2.26mL
50mM0.05mL0.23mL0.45mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet