SelectivePPARγreceptoragonist(EC50valuesare780and555nMatmurineandhumanPPARγreceptorsrespectively).DisplaysnoactivityatPPARαorPPARδreceptors.Antidiabeticagent;exertspotentglucose-loweringeffectsininsulin-resistantdiabeticmice.Displaysanti-invasiveeffectonhumanbreastcancercells;reducesmigration,adhesionandspreADIngonfibronectin-coatedplates.Alsoinhibitscellgrowthofhematopoieticcelllines.Inhibitslamellipodiaformationandactinpolymerization.
TroglitazoneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 441.54 |
Formula | C24H27NO5S |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 97322-87-7 |
PubChemID | 5591 |
InChIKey | GXPHKUHSUJUWKP-UHFFFAOYSA-N |
Smiles | CC1=C2C(CCC(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)(C)O2)=C(C)C(O)=C1C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 44.15 | 100 | |
ethanol | 4.42 | 10 |
Thefollowingdataisbasedontheproductmolecularweight441.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.26mL | 11.32mL | 22.65mL |
5mM | 0.45mL | 2.26mL | 4.53mL |
10mM | 0.23mL | 1.13mL | 2.26mL |
50mM | 0.05mL | 0.23mL | 0.45mL |