Nucleosideanalog;inhibitorofthymidylatesynthase.IncorporationofthetriphosphateformintoDNAinducesDNAfragmentation.Exhibitsantitumoractivity.
TrifluorothymidineisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 296.2 |
Formula | C10H11F3N2O5 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 70-00-8 |
PubChemID | 6708818 |
InChIKey | VSQQQLOSPVPRAZ-GFCOJPQKSA-N |
Smiles | O=C1C(C(F)(F)F)=CN(C2O[C@H](CO)[C@@H](O)C2)C(N1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 29.62 | 100 | |
water | 14.81 | 50 |
Thefollowingdataisbasedontheproductmolecularweight296.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.38mL | 16.88mL | 33.76mL |
5mM | 0.68mL | 3.38mL | 6.75mL |
10mM | 0.34mL | 1.69mL | 3.38mL |
50mM | 0.07mL | 0.34mL | 0.68mL |