请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Topotecan hydrochloride/4562/10/10 mg
产品编号:4562/10
市  场 价:¥1180.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$59.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Topotecan hydrochloride/4562/10/10 mg
商品介绍
Description:DNAtopoisomeraseIinhibitor;Camptothecin(Cat.No.1100)analog
AlternativeNames:SK&F104864-A
ChemicalName:10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DNAtopoisomeraseIinhibitor;inducesrapidapoptoticdeathinhumanB-lineageacutelymphoblasticleukemia(ALL)cells.ImprovessurvivalinthreemousemodelsofpoorprognosisALL;downregulatesB-MybandMycNexpressioninneuroblastomacells.Water-solubleanalogofCamptothecin(Cat.No.1100).Orallybioavailable.

TechnicalData

M.Wt457.91
FormulaC23H23N3O5.HCl
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber119413-54-6
PubChemID60699
InChIKeyDGHHQBMTXTWTJV-BQAIUKQQSA-N
SmilesOC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2)C2=C1CN(C)C.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO45.79100
water45.79100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight457.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.18mL10.92mL21.84mL
5mM0.44mL2.18mL4.37mL
10mM0.22mL1.09mL2.18mL
50mM0.04mL0.22mL0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet