DNAtopoisomeraseIinhibitor;inducesrapidapoptoticdeathinhumanB-lineageacutelymphoblasticleukemia(ALL)cells.ImprovessurvivalinthreemousemodelsofpoorprognosisALL;downregulatesB-MybandMycNexpressioninneuroblastomacells.Water-solubleanalogofCamptothecin(Cat.No.1100).Orallybioavailable.
M.Wt | 457.91 |
Formula | C23H23N3O5.HCl |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 119413-54-6 |
PubChemID | 60699 |
InChIKey | DGHHQBMTXTWTJV-BQAIUKQQSA-N |
Smiles | OC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2)C2=C1CN(C)C.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 45.79 | 100 | |
water | 45.79 | 100 |
Thefollowingdataisbasedontheproductmolecularweight457.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.18mL | 10.92mL | 21.84mL |
5mM | 0.44mL | 2.18mL | 4.37mL |
10mM | 0.22mL | 1.09mL | 2.18mL |
50mM | 0.04mL | 0.22mL | 0.44mL |