PotentATP-competitivePDGFRandVEGFRinhibitor(Ki=5and6nM,respectively);inhibitsphosphorylationofc-KitandsuppressesthegrowthofmastcelllinesexpressingmutantKit,inducingcellcyclearrestandapoptosis.AlsoinhibitsFGFR1(Ki=0.5μM).Effectiveinvivo.
SoldforresearchpurposesunderagreementfromPfizer.
M.Wt | 396.46 |
Formula | C22H25FN4O2 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 356068-94-5 |
PubChemID | 5329106 |
InChIKey | SRSGVKWWVXWSJT-ATVHPVEESA-N |
Smiles | O=C2NC1=CC=C(F)C=C1/C2=C/C3=C(C)C(C(NCCN4CCCC4)=O)=C(C)N3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 3.96 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight396.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.52mL | 12.61mL | 25.22mL |
5mM | 0.5mL | 2.52mL | 5.04mL |
10mM | 0.25mL | 1.26mL | 2.52mL |
50mM | 0.05mL | 0.25mL | 0.5mL |