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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Toceranib/3909/10/10 mg
产品编号:3909/10
市  场 价:¥4980.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>激酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$249.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Toceranib/3909/10/10 mg
商品介绍
Description:PotentPDGFRandVEGFRinhibitor
AlternativeNames:PallADIa
ChemicalName:5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentATP-competitivePDGFRandVEGFRinhibitor(Ki=5and6nM,respectively);inhibitsphosphorylationofc-KitandsuppressesthegrowthofmastcelllinesexpressingmutantKit,inducingcellcyclearrestandapoptosis.AlsoinhibitsFGFR1(Ki=0.5μM).Effectiveinvivo.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizer.

TechnicalData

M.Wt396.46
FormulaC22H25FN4O2
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber356068-94-5
PubChemID5329106
InChIKeySRSGVKWWVXWSJT-ATVHPVEESA-N
SmilesO=C2NC1=CC=C(F)C=C1/C2=C/C3=C(C)C(C(NCCN4CCCC4)=O)=C(C)N3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO3.9610mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight396.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.52mL12.61mL25.22mL
5mM0.5mL2.52mL5.04mL
10mM0.25mL1.26mL2.52mL
50mM0.05mL0.25mL0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet