Selectivefacilitatorof5-HTuptakeinvitroandinvivo.Hasnoaffinityforawiderangeofreceptors,including5-HTanddopamine(IC50>10μM)andhasnoeffectonnoradrenalinordopamineuptake.Antidepressant,analgesicandneuroprotectivefollowingsystemicadmiNISTrationinvivo.
| M.Wt | 458.93 |
| Formula | C21H24ClN2NaO4S |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 30123-17-2 |
| PubChemID | 23663953 |
| InChIKey | ZLBSUOGMZDXYKE-UHFFFAOYSA-M |
| Smiles | [Na+].CN1C2=CC=CC=C2C(NCCCCCCC([O-])=O)C2=CC=C(Cl)C=C2S1(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.58 | 10 | |
| ethanol | 4.58 | 10 | |
| water | 45.89 | 100 |
Thefollowingdataisbasedontheproductmolecularweight458.93.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.18mL | 10.89mL | 21.79mL |
| 5mM | 0.44mL | 2.18mL | 4.36mL |
| 10mM | 0.22mL | 1.09mL | 2.18mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |



