Antibioticthatinhibitsbacterialproteinsynthesis.InhibitsmRNA-tRNAtranslocationbyGTPaseelongationfactorG(EF-G),EF-TU(GTP)-catalyzedaa-tRNAdeliveryandtheactivityofinitiationfactor2(IF-2).Antitumoragent;inducescellcyclearrestandapoptosisinbreastcancercellsviadownregulationofFOXM1expression.
| M.Wt | 1664.89 |
| Formula | C72H85N19O18S5 |
| Storage | Storeat-20°C |
| Purity | ≥90%(HPLC) |
| CASNumber | 1393-48-2 |
| PubChemID | 16129666 |
| InChIKey | NSFFHOGKXHRQEW-DVRIZHICSA-N |
| Smiles | C=C(C(NC(C(N)=O)=C)=O)NC(C1=CSC(C2=NC(C3=CSC(C(C(C)OC(C4=CC(C(C)O)=C(C=CC(NC(C(NC(C)C(NC(C(NC(C)C5=O)=O)=C)=O)=O)C(C)CC)C6O)C6=N4)=O)N7)=N3)C(CC2)(N5)C8=NC(C(NC(C(N/C(C9=NC(C(NC(C(O)(C)C(C)O)C%10=NC(C7=O)=CS%10)=O)CS9)=C/C)=O)C(O)C)=O)=CS8)=N1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.65 | 10 |
Thefollowingdataisbasedontheproductmolecularweight1664.89.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.6mL | 3mL | 6.01mL |
| 5mM | 0.12mL | 0.6mL | 1.2mL |
| 10mM | 0.06mL | 0.3mL | 0.6mL |
| 50mM | 0.01mL | 0.06mL | 0.12mL |



