Anticancerandimmunosuppressiveagentoftenusedtotreatimmunedisordersandleukemia.Displayscytotoxicandantineoplasticproperties;disruptscytosinemethylationbyDNAmethyltransferasesafterincorporationintoDNA.SelectivelykillsBRCA2-defectivetumorsinaxenograftmodel.Alsofacilitatesproteasome-mediateddegradationofDNA(cytosine-5)-methyltransferase1(DNMT1).
M.Wt | 167.19 |
Formula | C5H5N5S |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 154-42-7 |
PubChemID | 2723601 |
InChIKey | WYWHKKSPHMUBEB-UHFFFAOYSA-N |
Smiles | NC1=NC(S)=C2C(NC=N2)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 16.72 | 100 |
Thefollowingdataisbasedontheproductmolecularweight167.19.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 5.98mL | 29.91mL | 59.81mL |
5mM | 1.2mL | 5.98mL | 11.96mL |
10mM | 0.6mL | 2.99mL | 5.98mL |
50mM | 0.12mL | 0.6mL | 1.2mL |