DNAmethylating,chemotherapeuticagent.Displaysantitumoractivityagainstaboardspectrumoftumors,includingleukemias,lymphomasandsolidtumors(IC50=5.0μMforcytotoxicityagainstmouseTLX5lymphomacells).Inducesautophagyinmalignantgliomacells.ExhibitsenhancedactivitywhenusedincombinationwithCHC(CatNo.5029).
TemozolomideisalsoofferedaspartoftheTocriscreenPlus,TocriscreenEpigeneticsToolboxandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 194.15 |
Formula | C6H6N6O2 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 85622-93-1 |
PubChemID | 5394 |
InChIKey | BPEGJWRSRHCHSN-UHFFFAOYSA-N |
Smiles | CN1N=NC2=C(N=CN2C1=O)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 9.71 | 50 |
Thefollowingdataisbasedontheproductmolecularweight194.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 5.15mL | 25.75mL | 51.51mL |
5mM | 1.03mL | 5.15mL | 10.3mL |
10mM | 0.52mL | 2.58mL | 5.15mL |
50mM | 0.1mL | 0.52mL | 1.03mL |