PotentP-glycoprotein(P-gp)inhibitor(IC50=5.1nM).ReversesdrugresistanceinmultipleMDRcelllines.Actsasasubstrateforbreastcancerresistanceprotein(BCRP)atlowconcentrationsandactsasaninhibitorofBCRPwhenusedat>100nMconcentration.Potentiatesthecytotoxiceffectsofdoxorubicin(Cat.No.2252)andmitoxantrone(Cat.No.4250)invitro.
M.Wt | 719.66 |
Formula | C38H38N4O6.2HCl |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
PubChemID | 121513890 |
InChIKey | ZJCJRGRTDKIFJJ-UHFFFAOYSA-N |
Smiles | O=C(C1=CC(OC)=C(OC)C=C1NC(C2=CN=C(C=CC=C3)C3=C2)=O)NC(C=C4)=CC=C4CCN5CC6=CC(OC)=C(OC)C=C6CC5.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 71.97 | 100 |
Thefollowingdataisbasedontheproductmolecularweight719.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.39mL | 6.95mL | 13.9mL |
5mM | 0.28mL | 1.39mL | 2.78mL |
10mM | 0.14mL | 0.69mL | 1.39mL |
50mM | 0.03mL | 0.14mL | 0.28mL |