Bcl-2inhibitor(Kivaluesare0.29μMand1.11μMforBcl-2andBcl-XLrespectively).Inhibitstheangiogenicpotentialofendothelialcellsinvitro.InducesS-phasearrestandapoptosisinpancreaticcancercelllines;alsoinhibitstheactivationofNotch-1andJagged-1invitroandinvivo.
| M.Wt | 573.7 |
| Formula | C33H35NO6S |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 877877-35-5 |
| PubChemID | 11455910 |
| InChIKey | PQAPVTKIEGUPRN-UHFFFAOYSA-N |
| Smiles | OC1=C(CC2=C(C(C)C)C=CC=C2)C=C(C(NC3=CC=C(S(C4=C(C(C)(C)C)C=CC=C4)(=O)=O)C=C3)=O)C(O)=C1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.37 | 100 | |
| ethanol | 2.87 | 5 |
Thefollowingdataisbasedontheproductmolecularweight573.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.74mL | 8.72mL | 17.43mL |
| 5mM | 0.35mL | 1.74mL | 3.49mL |
| 10mM | 0.17mL | 0.87mL | 1.74mL |
| 50mM | 0.03mL | 0.17mL | 0.35mL |



