Neuroprotectiveandneuroregenerativecompound.Rescuesmotorneuronsfromaxotomy-inducedcelldeathandpromotesnerveregenerationfollowingsciaticnervecrushinvivo.BindsdirectlytotwocomponentsofthemitochondrialpermeABIlitypore,thevoltage-dependentanionchannel(VDAC)andtranslocatorprotein;thoughttoinhibitMPTPopening.
M.Wt | 399.65 |
Formula | C27H45NO |
Storage | Desiccateat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 22033-87-0 |
PubChemID | 76971721 |
InChIKey | QNTASHOAVRSLMD-GYKMGIIDSA-N |
Smiles | [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]([H])4[C@@H](CCCC(C)C)C)=NO |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 19.98 | 50 | |
ethanol | 7.99 | 20 |
Thefollowingdataisbasedontheproductmolecularweight399.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.5mL | 12.51mL | 25.02mL |
5mM | 0.5mL | 2.5mL | 5mL |
10mM | 0.25mL | 1.25mL | 2.5mL |
50mM | 0.05mL | 0.25mL | 0.5mL |