Potent,selectiveandcompetitiveinhibitorofcytochromeP4501B1,anenzymeoverexpressedincertaintumors(IC50=6nM).50-and520-foldselectiveoverP4501A1and1A2respectively.Inhibitscancercellgrowthinvitro.
TMSisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 300.35 |
| Formula | C18H20O4 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 24144-92-1 |
| PubChemID | 5354004 |
| InChIKey | JDBCWSHYEQUBLW-AATRIKPKSA-N |
| Smiles | COC1=CC(OC)=C(C=CC2=CC(OC)=CC(OC)=C2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.04 | 100 | |
| ethanol | 7.51 | 25 |
Thefollowingdataisbasedontheproductmolecularweight300.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.33mL | 16.65mL | 33.29mL |
| 5mM | 0.67mL | 3.33mL | 6.66mL |
| 10mM | 0.33mL | 1.66mL | 3.33mL |
| 50mM | 0.07mL | 0.33mL | 0.67mL |



