Potent,selectiveandcompetitiveinhibitorofcytochromeP4501B1,anenzymeoverexpressedincertaintumors(IC50=6nM).50-and520-foldselectiveoverP4501A1and1A2respectively.Inhibitscancercellgrowthinvitro.
TMSisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 300.35 |
Formula | C18H20O4 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 24144-92-1 |
PubChemID | 5354004 |
InChIKey | JDBCWSHYEQUBLW-AATRIKPKSA-N |
Smiles | COC1=CC(OC)=C(C=CC2=CC(OC)=CC(OC)=C2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.04 | 100 | |
ethanol | 7.51 | 25 |
Thefollowingdataisbasedontheproductmolecularweight300.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.33mL | 16.65mL | 33.29mL |
5mM | 0.67mL | 3.33mL | 6.66mL |
10mM | 0.33mL | 1.66mL | 3.33mL |
50mM | 0.07mL | 0.33mL | 0.67mL |