Potentselectiveandrogenreceptormodulator(SARM)(IC50=30nM).Steroidalcompound.Exhibitslimitedeffectsonreproductivetissuesandsebaceousglands;doesnotrepressAP-1-sensitiveMMP-1reporter.Inhibits5α-reductasetypeIandII(IC50valuesare2and3nMrespectively).
M.Wt | 474.56 |
Formula | C27H33F3N2O2 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 188589-61-9 |
PubChemID | 10277123 |
InChIKey | YFBLEKKYWFJKBP-JZFZSVFHSA-N |
Smiles | O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](NC5=C(C(F)(F)F)C=CC=C5)=O)([H])N1C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 4.75 | 10 | |
ethanol | 4.75 | 10 |
Thefollowingdataisbasedontheproductmolecularweight474.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.11mL | 10.54mL | 21.07mL |
5mM | 0.42mL | 2.11mL | 4.21mL |
10mM | 0.21mL | 1.05mL | 2.11mL |
50mM | 0.04mL | 0.21mL | 0.42mL |