PotenthematopoieticprostaglandinDsynthase(H-PGDS)inhibitor(IC50=83nM).InhibitsPGD2productionandlatephasenasalblockageinananimalmodelofallergicrhinitis.ExhibitsnegligIBLeeffectsonCOX-1,COX-2,5-LOX,LTC4synthase,TXA2synthaseandmicrosomalprostaglandinE2synthase.
TFC007isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 487.55 |
Formula | C27H29N5O4 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 927878-49-7 |
PubChemID | 16040067 |
InChIKey | NLSSUSRERAMBTA-UHFFFAOYSA-N |
Smiles | O=C(C2CCN(C3=CC=C(NC(C4=CN=C(OC5=CC=CC=C5)N=C4)=O)C=C3)CC2)N1CCOCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 48.76 | 100 |
Thefollowingdataisbasedontheproductmolecularweight487.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.05mL | 10.26mL | 20.51mL |
5mM | 0.41mL | 2.05mL | 4.1mL |
10mM | 0.21mL | 1.03mL | 2.05mL |
50mM | 0.04mL | 0.21mL | 0.41mL |