PotentandselectiveSUV420H1/H2inhibitor(IC50valuesare25and144nMrespectively).Exhibits100-foldselectivityoverotherhistonemethyltransferasesandnon-epigenetictargets.Inhibitsthedi-andtri-methylationofH4K20meinmultiplecelllines(IC50<1μM).
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheA-196probesummaryontheSGCwebsite.
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofA196isreviewedontheChemicalProbeswebsite.
M.Wt | 359.25 |
Formula | C18H16Cl2N4 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1982372-88-2 |
Smiles | ClC1=CC2=C(C(C3=CC=NC=C3)=NN=C2NC4CCCC4)C=C1Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 7.18 | 20 |
Thefollowingdataisbasedontheproductmolecularweight359.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.78mL | 13.92mL | 27.84mL |
5mM | 0.56mL | 2.78mL | 5.57mL |
10mM | 0.28mL | 1.39mL | 2.78mL |
50mM | 0.06mL | 0.28mL | 0.56mL |