Agonistoftheconstitutiveandrostanereceptor(CAR)(EC50=20nM).InducesactivityofER1cytochromeP450isozymes,NADPH-cytochromecreductase,microsomalepoxidehydrolaseandglutathioneStransferase.Potentmitogen;induceslivercellproliferationinmice.
M.Wt | 402.06 |
Formula | C16H8Cl4N2O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 76150-91-9 |
PubChemID | 5382 |
InChIKey | BAFKRPOFIYPKBQ-UHFFFAOYSA-N |
Smiles | ClC(C=N3)=CC(Cl)=C3OC(C=C2)=CC=C2OC1=NC=C(Cl)C=C1Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 4.02 | 10 |
Thefollowingdataisbasedontheproductmolecularweight402.06.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.49mL | 12.44mL | 24.87mL |
5mM | 0.5mL | 2.49mL | 4.97mL |
10mM | 0.25mL | 1.24mL | 2.49mL |
50mM | 0.05mL | 0.25mL | 0.5mL |