Highaffinity5-HT2Areceptoragonist(Kivaluesare0.73and0.75nMforratandhumanreceptorsrespectively).PotentlystimulatesIP3accumulationinNIH3T3cellsstablyexpressingrat5-HT2Areceptors(EC50=36nM).Inducesheadtwitchesandhypothermiainmicefollowingi.p.adminitration.
TCB-2isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 353.05 |
Formula | C11H14BrNO2.HBr |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 912342-28-0 |
PubChemID | 71433791 |
InChIKey | TYMMXVZAUGQKRF-UHFFFAOYSA-N |
Smiles | Br.COC1=C2C(CN)CC2=C(OC)C(Br)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 35.3 | 100 | |
ethanol | 4.33 | 10 | |
water | 8.83 | 25 |
Thefollowingdataisbasedontheproductmolecularweight353.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.83mL | 14.16mL | 28.32mL |
5mM | 0.57mL | 2.83mL | 5.66mL |
10mM | 0.28mL | 1.42mL | 2.83mL |
50mM | 0.06mL | 0.28mL | 0.57mL |