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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/TC-S 7009/5243/10/10 mg
产品编号:5243/10
市  场 价:¥2780.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$139.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/TC-S 7009/5243/10/10 mg
商品介绍
Description:HighaffinityandselectiveHIF-2αinhibitor
ChemicalName:N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxADIazol-5-amine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityandselectiveHIF-2αinhibitor(Kd=81nM).BindstotheHIF-2αPAS-Bdomain;disruptsHIF-2α-ARNTheterodimerization.Exhibits>60-foldselectivityforHIF-2αoverHIF-1α.DecreasesHIF-2αDNA-bindingandattenuatesexpressionofHIF-2αtargetgenesinvitro.

CompoundLibraries

TC-S7009isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt308.65
FormulaC12H6ClFN4O3
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber1422955-31-4
PubChemID70697712
InChIKeyCDQUJZKBRAFWNG-UHFFFAOYSA-N
SmilesClC1=CC(F)=CC(NC3=C([N+]([O-])=O)C2=NON=C2C=C3)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO30.86100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight308.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.24mL16.2mL32.4mL
5mM0.65mL3.24mL6.48mL
10mM0.32mL1.62mL3.24mL
50mM0.06mL0.32mL0.65mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet