Potentandselectivesphingosine-1-phosphatereceptor1(S1P1)agonist(EC50=35nM),displays>100-foldselectivityagainstreceptorsubtypesS1P2-5.Inducesadose-dependentreductionincirculatingbloodlymphocytecountsinrodentmodels.Orallybioavailable.
TC-G1006isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight415.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.