GPR35agonist(pEC50valuesare7.59and8.36forβ-arrestinandGαq-i5Ca2+assaysrespectively).Displays1000-foldgreaterpotencyathumanGPR35receptorsrelativetomouseandratGPR35orthologsinanIP1accumulationassay.Morepotentthanzaprinast(Cat.No.0947).
M.Wt | 342.34 |
Formula | C17H11FN2O3S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 494191-73-0 |
PubChemID | 5766343 |
InChIKey | SYCKPHBALHXMIR-ZROIWOOFSA-N |
Smiles | O=C1N=C(NC3=CC=CC=C3F)S/C1=CC2=CC=C(C(O)=O)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 3.42 | 10 |
Thefollowingdataisbasedontheproductmolecularweight342.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.92mL | 14.61mL | 29.21mL |
5mM | 0.58mL | 2.92mL | 5.84mL |
10mM | 0.29mL | 1.46mL | 2.92mL |
50mM | 0.06mL | 0.29mL | 0.58mL |