Potent,reversibleinhibitoroffattyacidamidehydrolase(FAAH)(IC50valuesare28and100nMforhumanandratFAAHrespectively).Noncovalentinhibitor;displaysselectivityforFAAHovercannABInoid-relatedtargets(IC50>20μMforCB1,CB2andTRPV1).Activeinvivo.
TC-F2isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 439.51 |
Formula | C26H25N5O2 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 1304778-15-1 |
PubChemID | 25198728 |
InChIKey | NXTBLPPTZRPJCA-IBGZPJMESA-N |
Smiles | O=C(N(CC)C6=C5C=CC=C6)N5[C@H]1CCCN(C2=NC(C3=CC(C=CC=C4)=C4O3)=CC=N2)C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 43.95 | 100 |
Thefollowingdataisbasedontheproductmolecularweight439.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.28mL | 11.38mL | 22.75mL |
5mM | 0.46mL | 2.28mL | 4.55mL |
10mM | 0.23mL | 1.14mL | 2.28mL |
50mM | 0.05mL | 0.23mL | 0.46mL |