PotentandselectivePDE10Ainhibitor(IC50valuesare7.28,239,779,919,3100and3700nMatPDE10A,2A,11A,5A,7Band3Arespectivelyand>5000nMatPDE1B,4A,6,8Aand9A).ReversesMK801-inducedhyperactivityinvivo.
| M.Wt | 270.33 |
| Formula | C15H18N4O |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 959705-64-7 |
| PubChemID | 24802717 |
| InChIKey | YNADXFWEXJTQSZ-UHFFFAOYSA-N |
| Smiles | CC2=NC1=CC=C(OC)N=C1N3C2=C(C)N=C3CCC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 27.03 | 100 | |
| DMSO | 5.41 | 20 | |
| ethanol | 27.03 | 100 |
Thefollowingdataisbasedontheproductmolecularweight270.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.7mL | 18.5mL | 36.99mL |
| 5mM | 0.74mL | 3.7mL | 7.4mL |
| 10mM | 0.37mL | 1.85mL | 3.7mL |
| 50mM | 0.07mL | 0.37mL | 0.74mL |



