Proliferatingcellnuclearantigen(PCNA)inhibitor;inhibitsPCNA/PIP-boxpeptideinteraction(IC50~1μM).CausesDNAreplicationstressbystallingDNAreplicationforks.InhibitsPCNAinteractionwithDNApolymeraseδandarrestscellgrowthinS-phase.Suppressescancercellgrowth.
SoldunderlicensefromSt.JudeChildrensResearchHospital
M.Wt | 511.09 |
Formula | C15H15I2NO3 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 1380782-27-3 |
PubChemID | 71185540 |
InChIKey | NKOSKXJRVWVXRI-JTQLQIEISA-N |
Smiles | IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.HCl | 5.11 | 10mMwithgentlewarming | |
DMSO | 51.11 | 100 |
Thefollowingdataisbasedontheproductmolecularweight511.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.96mL | 9.78mL | 19.57mL |
5mM | 0.39mL | 1.96mL | 3.91mL |
10mM | 0.2mL | 0.98mL | 1.96mL |
50mM | 0.04mL | 0.2mL | 0.39mL |