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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/T2AA/4723/50/50 mg
产品编号:4723/50
市  场 价:¥11700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$585.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/T2AA/4723/50/50 mg
商品介绍
Description:PCNAinhibitor
ChemicalName:(βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Proliferatingcellnuclearantigen(PCNA)inhibitor;inhibitsPCNA/PIP-boxpeptideinteraction(IC50~1μM).CausesDNAreplicationstressbystallingDNAreplicationforks.InhibitsPCNAinteractionwithDNApolymeraseδandarrestscellgrowthinS-phase.Suppressescancercellgrowth.

LicensingInformation

SoldunderlicensefromSt.JudeChildrensResearchHospital

TechnicalData

M.Wt511.09
FormulaC15H15I2NO3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1380782-27-3
PubChemID71185540
InChIKeyNKOSKXJRVWVXRI-JTQLQIEISA-N
SmilesIC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl5.1110mMwithgentlewarming
DMSO51.11100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight511.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.96mL9.78mL19.57mL
5mM0.39mL1.96mL3.91mL
10mM0.2mL0.98mL1.96mL
50mM0.04mL0.2mL0.39mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet