Potent,highaffinityliverXreceptor(LXR)agonist(EC50~50nM,Kdvaluesare7and22nMforLXR-αandLXR-βrespectively).UpregulatesexpressionoftheABCA1geneassociatedwithcholesteroleffluxregulationandHDLmetabolism.Decreasesamyloid-βproductioninprimaryneuronsinvitro.DisplaysanEC50of~5μMforactivationofbileacidfarnesoidXreceptors(FXRs);10-foldmorepotentthannaturalFXRligandchenodeoxycholicacid.Alsoexhibitsinverseagonistactivityatconstitutiveandrostanereceptors(CAR).
T0901317isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 481.33 |
Formula | C17H12F9NO3S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 293754-55-9 |
PubChemID | 447912 |
InChIKey | SGIWFELWJPNFDH-UHFFFAOYSA-N |
Smiles | OC(C1=CC=C(C=C1)N(CC(F)(F)F)S(=O)(=O)C1=CC=CC=C1)(C(F)(F)F)C(F)(F)F |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 48.13 | 100 | |
ethanol | 48.13 | 100 |
Thefollowingdataisbasedontheproductmolecularweight481.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.08mL | 10.39mL | 20.78mL |
5mM | 0.42mL | 2.08mL | 4.16mL |
10mM | 0.21mL | 1.04mL | 2.08mL |
50mM | 0.04mL | 0.21mL | 0.42mL |