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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/T 0901317/2373/10/10 mg
产品编号:2373/10
市  场 价:¥1780.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$89.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/T 0901317/2373/10/10 mg
商品介绍
Description:PotentliverXreceptor(LXR)agoNIST;alsoCARinverseagonist
ChemicalName:N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,highaffinityliverXreceptor(LXR)agonist(EC50~50nM,Kdvaluesare7and22nMforLXR-αandLXR-βrespectively).UpregulatesexpressionoftheABCA1geneassociatedwithcholesteroleffluxregulationandHDLmetabolism.Decreasesamyloid-βproductioninprimaryneuronsinvitro.DisplaysanEC50of~5μMforactivationofbileacidfarnesoidXreceptors(FXRs);10-foldmorepotentthannaturalFXRligandchenodeoxycholicacid.Alsoexhibitsinverseagonistactivityatconstitutiveandrostanereceptors(CAR).

CompoundLibraries

T0901317isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt481.33
FormulaC17H12F9NO3S
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber293754-55-9
PubChemID447912
InChIKeySGIWFELWJPNFDH-UHFFFAOYSA-N
SmilesOC(C1=CC=C(C=C1)N(CC(F)(F)F)S(=O)(=O)C1=CC=CC=C1)(C(F)(F)F)C(F)(F)F

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO48.13100
ethanol48.13100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight481.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.08mL10.39mL20.78mL
5mM0.42mL2.08mL4.16mL
10mM0.21mL1.04mL2.08mL
50mM0.04mL0.21mL0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet